That Skinny Chick Can Bake
Mexican Chicken Manicotti - Pasta stuffed with creamy, spicy chicken and topped with melted cheese

Mexican Chicken Manicotti

If there’s a need for comfort food at the end of the day, this creamy Mexican Chicken Manicotti fits the bill. A Tex-Mex casserole is a tasty, easy meal!

This chicken casserole recipe is perfect for an easy weeknight meal or to deliver to friends or family who need a family friendly, delicious meal.

Mexican Chicken Manicotti on a white basket weave plate with a red handled fork

The Story of Ryan, Ashley and Miles

Sometimes there are causes that you just cannot ignore. If you’re not familiar with Ryan, Ashley and little Miles, here is a story you won’t soon forget. When Ashley was pregnant with their first child, her husband, a young, and up to this point, very healthy guy, Ryan, was diagnosed with stage 4 colon cancer.

Then 8 weeks after this dire diagnosis, their sweet son was born. Baby Miles was diagnosed with renal failure, Primary Hyperoxaluria and needed a liver and kidney transplant for long term survival. Any one of these diagnoses would pull at your heart strings, but two? In one year? Devastating.

Mexican Chicken Manicotti on a white plate with a forkful of manicotti

How to Help

If the Wagner family lived nearby, I’d be baking and cooking up a storm. Isn’t that what we all like to do to offer comfort? Dropping off a loaf of banana bread or a casserole ready to pop in the oven.

That’s what my blogger friends and I are doing today—sharing comfort food, like this Mexican chicken manicotti, and asking our friends and readers to donate to a worthy cause. Please consider donating even just your Starbucks’ allotment for the week. Every penny will help get Miles closer to a cure. And I’m certain they’d welcome your prayers, too.

If you’d like to read more about their story, here is the blog post where Ashley talks about Ryan’s diagnosis and the first fundraiser to help them through his treatment. And another post when she detailed learning about Miles’ genetic illness after rushing him to the ER post seizure. I’m certain that just looking at precious Miles’ beautiful face will convince you to help in some way. Thank you, all.

Mexican Chicken Manicotti

This is definitely fusion food.  Italian manicotti is filled with spicy Tex-Mex chicken in a creamy sauce. Topped with loads of cheese, this Mexican chicken manicotti, this “casserole” will please young and old alike.

Like pasta? Check. Mexican? Check. Make this Tex-Mex casserole for someone you care about or your own family!

Mexican Chicken Manicotti in a white ceramic casserole dish

 More Comfort Food from My Blogger Friends


Mexican Chicken Manicotti in a white rectangular casserole dish


Love this recipe? Please consider rating it in the comments below. You can also follow me on Facebook, Pinterest and Instagram.

Mexican Chicken Manicotti in a white ceramic casserole dish

Mexican Chicken Manicotti

Manicotti shells filled with creamy, spiced up chicken and topped with gooey cheese!

  • Author: Liz Berg
  • Prep Time: 20 minutes
  • Cook Time: 60 minutes
  • Total Time: 1 hour 20 minutes
  • Yield: 6 servings 1x
  • Category: Entree
  • Method: Baking
  • Cuisine: Mexican


  • 1 (16-ounce) package manicotti shells
  • 1 onion, chopped
  • 3 cloves garlic, minced
  • 12 jalapeño peppers, minced
  • 2 tablespoons butter
  • 2 cups shredded cooked chicken (can use a rotisserie chicken)
  • 1 (8-ounce) package cream cheese, at room temperature
  • 1/4 cup sour cream
  • 11/3 cups salsa, divided
  • 1 (8-ounce) can enchilada sauce
  • 3/4 cup shredded Monterey Jack cheese
  • 3/4 cup shredded sharp cheddar cheese
  • 1/4 cup shredded Parmesan cheese


  1. Preheat oven to 350 degrees F. Spray a 13″ x 9″ pan with nonstick cooking spray and set aside. Bring a large pot of salted water to a boil.
  2. In large skillet, cook onion, garlic, and jalapeños in butter until softened. Remove from heat and stir in chicken, cream cheese, and sour cream; stir until blended. Let cool 20 minutes, then add 1/3 cup salsa.
  3. Cook the manicotti shells until almost al dente according to package directions; drain. Stuff the shells with the chicken mixture.
  4. In small bowl, combine remaining cup of salsa and enchilada sauce; mix well. Place 1/2 cup of this mixture into the bottom of prepared pan. Top with stuffed manicotti shells. If there is leftover chicken filling, just put it on top of the stuffed shells. Pour remaining sauce mixture over and sprinkle with both cheeses.
  5. Bake for 35-40 minutes until mixture is bubbly and cheese is browned.


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23 comments on “Mexican Chicken Manicotti”

  1. Liz!!! Thank you so much for writing this awesome post and making this crazy good manicotti! It’s like you married my two favorite foods. Your recipe looks amazing and I’m so glad I got to work with you on this 🙂

  2. This looks amazingly delicious and comforting!

  3. What a great cause. I know they will meet their goal with all of you helping. Also want to say that it looks like they would be well fed! What great recipes to choose from. This looks great. Love the manicotti instead of tortillas.

  4. LOVE Manicotti! Haven’t made it in years and love the Mexican twist!! Great working on this project with you!

  5. Ryan, Ashley, and Miles are definitely in my thoughts and prayers. I love your Mexican twist on an Italian favorite. 😀

  6. Such a perfect comfort meal! I love the Mexican twist on manicotti. I made it once but with beef. Can’t wait to try it with chicken!

  7. I was hungry before, now I’m starving! Pinned to make. Yum!!

  8. Oh my goodness Liz, I could eat the whole pan myself, what a great recipe!

  9. This manicotti looks absolutely out of control-amazing, Liz! I love the Mexican flair to such a classic Italian dish. And I love the Wagner family – sending them LOTS of prayers!

  10. Love the idea of a Meixcan manicotti. Such a great idea and so perfect for bring over to someone that needs it. Glad we could partner on this!

  11. I am all about a comfort meal and I love this Mexican twist on manicotti!

  12. Looks delish… all of your posts do!!!!!

  13. These look and sound amazing, Liz! I hope all goes well for the Wagner family.

  14. Manicotti is one of my very favorite Italian dishes! Never thought about putting a Mexican twist on it! So delicious! Glad we were able to put together these posts for Ashley and her family!

  15. Donated. Thank you for playing angel and drawing attention to a family who needs lots of comfort <3

  16. This is so heartbreaking ..Great cause Liz.. we all should try our best and help in this horrible situation but then again everything happens for a reason and I’m sure they will get out of this stronger. Loved your recipe.

  17. What a wonderful cause Liz! Plus a fantastic recipe! I wish Ryan and his family all the best in receiving excellent medical care for their needs.

  18. I’m having the ladies over for dinner next Monday, I bet they would just love this dish. It’s so nice that you are hosting the fundraiser in your blog, it really is such a tragic story, one that definitely makes me grateful for my health and JT’s health.

  19. This looks incredibly delicious. I know my family would love it!

  20. I love your Mexican twist on one of my favorite Italian dinners, Liz! It was a blessing to participate in this event with you <3

  21. This is such a wonderful cause, Liz. Thank you for sharing Ryan’s story with us, I sincerely hope they reach their goal and he receives the best medical care that he needs.
    This manicotti looks like the perfect comforting dish. Love the Mexican twist.

  22. Liz … this meal is amazing!!! I love Italian, I love Mexican … this is a home run! Adding this to the menu SOON!!
    It’s been a pleasure to collaborate with so many awesome bloggers – like you! – to help one of our own. Have a wonderful day!

  23. I liked them because I like Mexican food. This was easy to make and tastes soooo good!

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